To turn off genes, researchers use a protein called Cas9 coupled to a variety of short RNA molecules. The technique, called CRISPR interference, blocks the production of messenger RNA by the enzyme RNA polymerase, preventing targeted genes from making their encoded proteins.
Credit: UCSF
Technical advances in DNA sequencing and genomics have given scientists access to troves of information about genetic changes in tumors.
from Cancer Information - CRISPR: Genome Editing Comes of Age - National Cancer Institute
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